Efficient direct 2,2,2-trifluoroethylation of indoles via C-H functionalization.
نویسندگان
چکیده
A novel highly C3 selective metal free trifluoroethylation of indoles using 2,2,2-trifuoroethyl(mesityl)-iodonium triflate was developed. The methodology enables the introduction of a trifluoroethyl group in a fast and efficient reaction under mild conditions with high functional group tolerance. Beyond the synthetic developments, quantum chemical calculations provide a deeper understanding of the transformation.
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عنوان ژورنال:
- Chemical communications
دوره 51 21 شماره
صفحات -
تاریخ انتشار 2015